Публікація: Reactive Oxygen Species Scavenging by Small Gadolinium-Yttrium Orthovanadate Nanocrystals
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Дата
2022
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Анотація
Oxidative stress induced by reactive oxygen
species (hydrogen peroxide, superoxide anion, hydroxyl radical
etc.) is the key factor in developing a variety of pathological
conditions including diabetes, asthma, atherosclerosis,
hypertension mellitus and cancer. To prevent or reduce the cell
damages caused by reactive oxygen species, natural or
synthetic molecules named antioxidants are commonly used.
Recently, various inorganic nanomaterials, such as CeO2,
Mn3O4, Co3O4 and Fe3O4 nanocrystals, have attracted growing
interest as nano-antioxidants with reactive oxygen species
regulating ability.
Here, we report on high antioxidant behavior of small
gadolinium-yttrium orthovanadate nanocrystals revealed by
spectroscopic methods using various reactive oxygen species
sensors, and propose the mechanism describing their reactive
oxygen species scavenging action.
It has been found that in 2 nm gadolinium-yttrium
orthovanadate nanocrystals more than 60% vanadium ions are
presented in lower V4+ and V3+ oxidation states. Switching
between V3+↔V4+ and V4+↔V5+ oxidation states allow
gadolinium-yttrium orthovanadate nanocrystals to react with
hydrogen peroxide (H2O2) and superoxide anion (O2
•-) in
enzyme-like manner and neutralize hydroxyl radical (•OH),
and peroxyl radicals (ROO•), as well.
The obtained data and proposed mechanism of gadoliniumyttrium
orthovanadate nanocrystals antioxidant action can
explain the non-trivial anti-aging and radioprotective effects of
gadolinium-yttrium orthovanadate nanocrystals observed
earlier in vivo.
Опис
Ключові слова
reactive oxygen species, nano-antioxidants, orthovanadate nanocrystals
Бібліографічний опис
Reactive Oxygen Species Scavenging by Small Gadolinium-Yttrium Orthovanadate Nanocrystals / P. Maksimchuk, A. Onishchenko, K. Hubenko, A. Aslanov, S. Yefimova, V. Seminko, V. Klochkov // 2022 IEEE 12th International Conference “Nanomaterials: Applications & Properties” (IEEE NAP-2022) Krakow, Poland, Sep. 11-16.