Reactive Oxygen Species Scavenging by Small Gadolinium-Yttrium Orthovanadate Nanocrystals

Maksimchuk, P.; Hubenko, K.; Seminko, V.; Onishchenko, A.; Aslanov, A.; Klochkov, V.

Публікація:
Reactive Oxygen Species Scavenging by Small Gadolinium-Yttrium Orthovanadate Nanocrystals

dc.contributor.author	Maksimchuk, P.
dc.contributor.author	Hubenko, K.
dc.contributor.author	Seminko, V.
dc.contributor.author	Onishchenko, A.
dc.contributor.author	Aslanov, A.
dc.contributor.author	Klochkov, V.
dc.date.accessioned	2023-03-18T19:02:58Z
dc.date.available	2023-03-18T19:02:58Z
dc.date.issued	2022
dc.description.abstract	Oxidative stress induced by reactive oxygen species (hydrogen peroxide, superoxide anion, hydroxyl radical etc.) is the key factor in developing a variety of pathological conditions including diabetes, asthma, atherosclerosis, hypertension mellitus and cancer. To prevent or reduce the cell damages caused by reactive oxygen species, natural or synthetic molecules named antioxidants are commonly used. Recently, various inorganic nanomaterials, such as CeO2, Mn3O4, Co3O4 and Fe3O4 nanocrystals, have attracted growing interest as nano-antioxidants with reactive oxygen species regulating ability. Here, we report on high antioxidant behavior of small gadolinium-yttrium orthovanadate nanocrystals revealed by spectroscopic methods using various reactive oxygen species sensors, and propose the mechanism describing their reactive oxygen species scavenging action. It has been found that in 2 nm gadolinium-yttrium orthovanadate nanocrystals more than 60% vanadium ions are presented in lower V4+ and V3+ oxidation states. Switching between V3+↔V4+ and V4+↔V5+ oxidation states allow gadolinium-yttrium orthovanadate nanocrystals to react with hydrogen peroxide (H2O2) and superoxide anion (O2 •-) in enzyme-like manner and neutralize hydroxyl radical (•OH), and peroxyl radicals (ROO•), as well. The obtained data and proposed mechanism of gadoliniumyttrium orthovanadate nanocrystals antioxidant action can explain the non-trivial anti-aging and radioprotective effects of gadolinium-yttrium orthovanadate nanocrystals observed earlier in vivo.
dc.identifier.citation	Reactive Oxygen Species Scavenging by Small Gadolinium-Yttrium Orthovanadate Nanocrystals / P. Maksimchuk, A. Onishchenko, K. Hubenko, A. Aslanov, S. Yefimova, V. Seminko, V. Klochkov // 2022 IEEE 12th International Conference “Nanomaterials: Applications & Properties” (IEEE NAP-2022) Krakow, Poland, Sep. 11-16.
dc.identifier.uri	https://openarchive.nure.ua/handle/document/22429
dc.language.iso	en
dc.subject	reactive oxygen species, nano-antioxidants, orthovanadate nanocrystals
dc.title	Reactive Oxygen Species Scavenging by Small Gadolinium-Yttrium Orthovanadate Nanocrystals
dc.type	Article
dspace.entity.type	Publication