Перегляд за автором "Klochkov, V."

Зараз показано 1 - 4 з 4
  • Зображення мініатюри
    Публікація
    Effect of Hydrogen Peroxide Decomposition on Luminescence and Microstructure of GdVO4:Eu3+ Redox-Active Nanocrystals
    (Institute of Electronics and Computer Sciences, 2024) Hubenko, K.; Maksimchuk, P.; Klochkov, V.; Onishchenko, A.; Yefimova, S.
  • Зображення мініатюри
    Публікація
    Hydroxyl radicals scavenging by small oxide | nanocrystals with variable valence ions
    (Nanocomposites and Nanomaterials, 2022) Maksimchuk, P.; Hubenko, K.; Seminko, V.; Onishchenko, A.; Bespalova, I.; Klochkov, V.; Yefimova, S.
    The efficiency of hydroxyl radicals scavenging by small oxide nanocrystals with variable valence ions (CeO2, GdYVO4 and TiO2) in water solutions allows suggesting such materials as effective antioxidants in living cells as well.
  • Зображення мініатюри
    Публікація
    Radioprotective Properties of Oxide Nanocrystals
    (University of Milano, 2024) Hubenko, K.; Maksimchuk, P.; Klochkov, V.; Bespalova, I.; Onishchenko, A.; Demchenko, L.; Yefimova, S.
  • Зображення мініатюри
    Публікація
    Reactive Oxygen Species Scavenging by Small Gadolinium-Yttrium Orthovanadate Nanocrystals
    (2022) Maksimchuk, P.; Hubenko, K.; Seminko, V.; Onishchenko, A.; Aslanov, A.; Klochkov, V.
    Oxidative stress induced by reactive oxygen species is the key factor in developing a variety of pathological conditions including diabetes, asthma, atherosclerosis, hypertension mellitus and cancer. To prevent or reduce the cell damages caused by reactive oxygen species, natural or synthetic molecules named antioxidants are commonly used. Recently, various inorganic nanomaterials, such as CeO2, Mn3O4, Co3O4 and Fe3O4 nanocrystals, have attracted growing interest as nano-antioxidants with reactive oxygen species regulating ability. Here, we report on high antioxidant behavior of small gadolinium-yttrium orthovanadate nanocrystals revealed by spectroscopic methods using various reactive oxygen species sensors, and propose the mechanism describing their reactive oxygen species scavenging action. It has been found that in 2 nm gadolinium-yttrium orthovanadate nanocrystals more than 60% vanadium ions are presented in lower V4+ and V3+ oxidation states. Switching between V3+↔V4+ and V4+↔V5+ oxidation states allow gadolinium-yttrium orthovanadate nanocrystals to react with hydrogen peroxide (H2O2) and superoxide anion (O2•-) inenzyme-like manner and neutralize hydroxyl radical (•OH),and peroxyl radicals (ROO•), as well. The obtained data and proposed mechanism of gadoliniumyttrium orthovanadate nanocrystals antioxidant action canexplain the non-trivial anti-aging and radioprotectiv effects of gadolinium-yttrium orthovanadate nanocrystals observedearlier in vivo.