Перегляд за автором "Khmil, N. V."

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  • Зображення мініатюри
    Публікація
    Binding characteristics of systemic glucocorticoids with the SARS-CoV-2 spike glycoprotein: in-silico evaluation
    (2024) Khmil, N. V.; Boiechko-Nemovcha, A. O.; Kolesnikov, V. G.
    The aim of the study was to evaluate the binding characteristics of systemic glucocorticoids with the SARS-CoV-2 S protein and to elucidate the topological features of non-covalent ligandprotein complexes.
  • Немає доступних мініатюр
    Публікація
    Effect of local anesthetics on cells hydration at drug-receptor reactions
    (Ivan Franko National University of Lviv, 2016) Soloshenko, E. N.; Kondakov, A. K.; Khmil, N. V.; Kolesnikov, V. G.; Shevchenko, Z. M.; Yarmak, T. P.
    By means of EHF-dielectrometry method it is shown that stimulation of red blood cells by articaine, ubistesin and septonest has been differently reflected in change of a real part of permittivity (). Findings by method EHF-dielectrometry and also erythrocyte sedimentation rate were good correlated (r  0,92) that allows to recommend this radio physical method for diagnostics of early revealing of a sensitization to medicinal allergens
  • Немає доступних мініатюр
    Публікація
    Erythrocytes’ permittivity for determination of sensitization to local anesthetics of amide and ether groups
    (Yuriy Fedkovych Chernivtsi National University Chernivtsi, Ukraine, 2017) Soloshenko, E. N.; Kondakova, A. K.; Khmil, N. V.; Kolesnikov, V. G.; Shevchenko, Z. M.; Yarmak, T. P.
    The work presents results of experimental investigations of erythrocytes’ permittivity to the influence of local anesthetics amide and ether groups, since unclarity of the mechanisms of action of these drugs on molecular and cellular level remain and also serious allergic reactions in dentistry are observed. EHF-dielectrometry (K-band, 37,5 GHz) in contrast to traditional biochemical and immunoenzyme test-systems ensures rapid analysis of real part of erythrocytes’ permittivity () which determine of definite molecules’ polarizability in external alternating electric field. In our experiment we observe the decrease  in erythrocytes’ suspension at action procaine (c=500mcg/ml) concerning control samples. The lidocaine’s action (c=500mcg/ml) results in more marked decrease  in erythrocytes’ structures concerning procaine’s action possibly due to additional hydrating of organic molecule with amide bond.
  • Немає доступних мініатюр
    Публікація
    The investigation of dielectric constant of blood during sensitization to penicillin G
    (Львів, 2019) Soloshenko, E. N.; Kondakova, A. K.; Kolesnikov, V. G.; Khmil, N. V.; Shevchenko, Z. M.; Yarmak, T. P.
    The aim of this work was to evaluate the effect of penicillin G on the patients’ blood with antibiotic sensitization in a history in vitro using the parameters of dielectric constant. To study the dielectric constant, venous blood was used in 23 patients with antibiotic sensitization between the ages of 35 and 50 years. Sensitization to penicillin G in these patients was confirmed by the method of leukocyte agglomeration reaction (LAR) and by estimating the erythrocyte sedimentation rate (ESR) loaded with the suspected allergen.