Публікація: Progress and chellenges in electrochemiluminescent aptasensors
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Дата
2017
Назва журналу
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Видавництво
PII: S0956-5663(17)30015-5 DOI: http://dx.doi.org/10.1016/j.bios.2017.01.015 Reference: BIOS9480
Анотація
The importance of developing new diagnostic and detection technologies for the
growing number of sensing challenges is rising each year. Here, we present a
comprehensive and concise review on electrochemiluminescent (ECL) aptasensors by
putting special emphasis on its characteristic features, advances, challenges, and
applications of ECL based aptasensors. ECL is an ideal tool for constructing such
sensors because of its inherent characteristics and can be easily integrated into
aptamer based sensing platforms. This review summarizes the "synergistic benefits"
of ECL aptamer-based sensors; classifications of ECL aptamer-based assay designs,
and signal amplification strategies. This critical review highlights the effects of
integration of nanomaterials, immobilization techniques, and amplification/detection
strategies on the analytical performance of ECL based aptasensors. Moreover, several
proof-of-concepts with appropriate figures and explanations have been shown to
provide a general guide for the design of ECL aptasensors, and to stimulate further
application of these ECL aptasensors. Finally, we conclude with the remaining
challenges and opportunities to inspire further developments in ECL aptasensors.
Опис
Ключові слова
diagnostic and detection technologies, aptasensor, ECL
Бібліографічний опис
: Kateryna Muzyka, Muhammad Saqib, Zhongyuan Liu, Wei Zhang and Guobao Xu, PROGRESS AND CHALLENGES IN ELECTROCHEMILUMINESCENT APTASENSORS, Biosensors and Bioelectronic, http://dx.doi.org/10.1016/j.bios.2017.01.015