Soloshenko, E. N.Kondakova, A. K.Khmil, N. V.Kolesnikov, V. G.Shevchenko, Z. M.Yarmak, T. P.2019-12-202019-12-202017Erythrocytes’ permittivity for determination of sensitization to local anesthetics of amide and ether groups / E.N. Soloshenko, A. K. Kondakova, N. V. Khmil, V. G. Kolesnikov, Z. M. Shevchenko, T . P. Yarmak // 5th International research and practice conference nanotechnology and nanomaterials NANO-2017 August 23 - 26, 2017, Yuriy Fedkovych Chernivtsi National University Chernivtsi, Ukraine, P. 613http://openarchive.nure.ua/handle/document/10458The work presents results of experimental investigations of erythrocytes’ permittivity to the influence of local anesthetics amide and ether groups, since unclarity of the mechanisms of action of these drugs on molecular and cellular level remain and also serious allergic reactions in dentistry are observed. EHF-dielectrometry (K-band, 37,5 GHz) in contrast to traditional biochemical and immunoenzyme test-systems ensures rapid analysis of real part of erythrocytes’ permittivity () which determine of definite molecules’ polarizability in external alternating electric field. In our experiment we observe the decrease  in erythrocytes’ suspension at action procaine (c=500mcg/ml) concerning control samples. The lidocaine’s action (c=500mcg/ml) results in more marked decrease  in erythrocytes’ structures concerning procaine’s action possibly due to additional hydrating of organic molecule with amide bond.enErythrocytes’ permittivitysensitizationlocal anesthetics of amide and ether groupsAbstract of Thesis